What are the risk factors for refractory status epilepticus and how often is intubation required?

Takeaway

Inadequate first- and second-line treatment, and higher modified Rankin Scale (mRS) prior to status epilepticus increased chances of presentation of refractory status epilepticus (RSE), and among those with RSE the majority did not require intubation during treatment.

Why this matters

  • RSE is defined as status epilepticus that is resistant to first- and second-line treatments and often intubation and general anesthesia is recommended.

  • This prospective, multicentric analysis from the largest known population of adults with RSE, identified factors that could possibly prevent RSE development such as following the guidelines on choice of the initial treatment.