Understanding gait impairment and its clinical implications in hereditary spastic paraplegia

Takeaway

  • Hereditary spastic paraplegia (HSP) is associated with significant gait impairments which correlate with disease severity.

Why this matters?

  • HSP is group of rare genetic diseases with wide variability in age of onset, rate of progression, and clinical phenotypes. Progressive lower limb spasticity and weakness are common clinical hallmarks across HSP. Over time, this leads to gait disorder and, for many, loss of ambulation.

  • To date, there has been a lack of understanding surrounding the feasibility and clinical potential of gait parameters in HSP patients. Determining correlation between gait parameters and clinical scores offers another mechanism to assess HSP, subsequently increasing clinical understanding of longitudinal changes in gait in HSP and its associated outcomes.