In cognitively unimpaired older individuals, white matter lesion burden plays a central role in the degeneration of cholinergic pathways.
Why this matters
Several pathological processes might contribute to the degeneration of the cholinergic system in aging, including white matter lesions. However, how they may influence cognitive performance is unclear.
These findings may aid the development of prevention programs for neurodegeneration and cognitive impairment, eventually guiding therapeutic decisions.