How do lifestyle factors influence the risk of developing age-associated cognitive decline?


  • Cognitive reserve is influenced by lifestyle activity factors and this relationship may be moderated by both sex and APOE4-carrier status.

Why this matters

  • A physically and cognitively active lifestyle may reduce the risk of age-associated cognitive decline, delaying dementia onset and increasing cognitive reserve.

  • However, determining whether the association between lifestyle activities and cognitive reserve differs by sex and APOE4-carrier status is not well studied and elucidating this further could lead to more precise clinician interventions to help prevent cognitive decline in old age.