Health-related quality of life in multiple sclerosis: can we predict risk of the worst trajectories?


  • Using group-based trajectory modeling in a large multiple sclerosis (MS) cohort, the authors identified early risk factors of developing worse mental or physical health-related quality of life (HRQoL), such as age at diagnosis and income.

Why this matters

  • MS is a chronic disease with variable outcomes that can place a large burden on the individual with regard to quality of life – affected individuals report lower HRQoL than the general population.

  • This study provides evidence that heterogeneous HRQoL trajectories in MS can be clustered and it is possible to identify the early risk factors for those groups on the poorest trajectories, potentially allowing early clinical intervention.